General
Dubin–Johnson syndrome is an inherited disorder. It is associated with liver impairment, resulting in characteristic yellowing of the skin and mucous membranes. The condition is very rare and occurs most frequently in individuals of Jewish origin. Dubin–Johnson syndrome is caused by a mutation in a gene that normally enables the transport of the bile pigment bilirubin into bile.
Diagnosis
Diagnosis of the disorder is based on the symptoms listed below. Genetic testing targeting the specific mutated gene may also be performed.
Treatment
Unfortunately, treatment of this syndrome is not possible because it is an inherited condition. However, the prognosis is good and the syndrome itself does not endanger life. Patients with this syndrome should avoid excessive alcohol consumption, fatty foods, and the use of certain medications, such as hormonal contraception.
- hromadenie bilirubínu v tele
- žltačka
- porucha funkcie pečene
- zvýšenie hladín pečeňových enzýmov
- bolesti brucha
- nechuť do jedla
- vracanie, nevoľnosť a pocit na vracanie
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